Aminoglycoside antibiotics bind to the influenza A virus RNA promoter.
نویسندگان
چکیده
Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent lead compounds for the discovery of antiviral therapeutics against influenza A virus.
منابع مشابه
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عنوان ژورنال:
- Molecular bioSystems
دوره 8 11 شماره
صفحات -
تاریخ انتشار 2012